14 articles in this category
Vascularized organoids are a mess. That's fine—they're supposed to be. But when you're staring at your data and wondering why the readout varies betwe...
You've seeded the cells, built the vasculature, maybe even watched capillaries sprout under the microscope. But at day 14, the growth curve flattens. ...
Every vascularized organoid platform starts with a promise: blood vessels that feel real. But real vessels don't see a neat, constant shear stress. Th...
You seed endothelial cells, wait a week, and then the trouble starts. One side of your organoid is flush with perfused capillaries; the other side loo...
So you're running long-term organoid cultures—say, 60 days or more. And you've noticed something off. Maybe the lumens inside your vascularized organo...
You've built the vascularized organoid. You've got flow. And then — the perfusion curve that should rise with metabolic demand starts flatlining. Or w...
You set your perfusion pump to deliver 2 dyne/cm² at noon on day one. By hour 72, your organoid's lumen has ballooned, your endothelial markers are fa...
Imagine building a city where the roads keep shifting. That's what happens when we try to grow blood vessels in organoids. The tip cells—those leading...
You have a vascularized organoid platform humming along. Day 14, capillaries are wrapping around the budding crypts. Then you read a paper: 'Physioxia...
You have a vascularized organoid on the chip. It looks healthy. But a nagging question: is the flow going the right way? Most protocols assume blood e...
If you are building a vascularized organoid, you have two starkly different ways to get blood vessels in. Let the endothelial cells self-organize into...
You have spent months coaxing stem cells into a miniature liver. The organoid looks good. Then you hook up the flow. Twenty-four hours later, the pare...
Picture this: Tuesday afternoon, you check the confocal stack of your day-14 vascularized organoid. The vessel front—that leading edge of CD31-positiv...
You grow a beautiful vascularized organoid. Bright red lectin staining, nice branching. Then you add a drug and the whole thing lights up like a Chris...