Reader Notes: Theranostic Biomaterial Interfaces Edge Cases
The immune system doesn't hold still. It drifts—between hours, between doses, between patients. Yet most theranostic interfaces still read out like a photograph: a single moment, frozen in time. That mismatch is starting to hurt. This is about a choice. You're a researcher, a device engineer, or a clinical decision-maker. You've got a surface that's supposed to diagnose and treat, but your readouts are telling you where the immune system was, not where it's going. The question isn't whether immune drift matters—it's whether you can afford to keep ignoring it. Who Actually Has to Make This Call—and When Stakeholders: Researchers, Clinicians, Device Teams The person who owns this decision is rarely the person who sees the drift first. In my experience, the lab researcher spots the anomaly—a fluorescent signal wandering off baseline—but they don't have authority to swap readouts mid-study.